ABSTRACT
ntroduction:West Nile Virus (WNV) infection is an important arthropod-borne zoonosis viral disease. This virus is neglected in Yemen especially in Hodeidah.Aim of the Study:The purpose of this study was to detect WNV infection,determinethe epidemiological and clinical characteristics within febrile patients in Hodeidah city and to determine some risk factors associatedwith WNVinfection.Materials and Methods: 136 febrile patients in a hospital base study were diagnosed in Center of Tropical Medicine and Infectious Diseases (CTMID), Authority of General Al-Thawara Hospital Hodeidah, Yemen from January of 2017 to December of 2017. WNV infection was detected by enzyme linkage immune sorbent assay (ELISA) on serum samples. Results and Discussion:The results showed that 5 cases (3.67%) were WNV –positive namely IgM thatwas detected inwinter and spring seasons,the most prevalent antibodies of WNVwere IgG namely 75 cases (55.14%). Most common symptoms were fever, headache, fatigue, weakness, arthralgia, myalgiaand photophobia. The treatment based on the intravenoustherapy (IV)with anti-pyritic,plasma in some cases and all cases were recovered whilemortality rate was 00%. Conclusion:WNVwas detected in Hodeidah which placed in Tehama "western Yemen", as first time by our preliminary study that confirmed the evidence of WNV IgM and IG antibodies presence on 2017, in order to increase safety of diagnosis of febrile diseases, it is essential to continue surveillance of this emerging infection, suggesting that this emergence has been transported by migratory birds from winteringareas to Tehama region.